Startup Guide Summit returns to Lisbon for its fourth edition, asking one question: can Europe build the systems it depends on ethically and still compete?
Energy, health, food, care, mobility, and the platforms where public life now happens. These are the systems everything else rests on, and AI is being built into all of them at once, mostly by companies optimising for scale.
Hosted at Casa do Impacto during Web Summit week, the summit brings together 200+ founders, investors, policymakers, ecosystem builders and community leaders from across the continent for an afternoon of debate, working sessions, a pitch competition and celebration.


“
Europe's bet is that being human is an advantage, not a bottleneck. The way we build, collaboratively, across borders, with people at the centre, can be our edge rather than a tax on our speed.
But critical systems have to be fast to build and slow to fail. A bet on values only pays out if Europe can afford to place it. This summit asks that question honestly, and puts the optimists and the sceptics in the same room.
”

THEME
The Human Advantage – Building the critical systems for a resilient Europe
This year's Summit is built around one question:
Can Europe be both ethical and competitive in building the systems it depends on?
The infrastructure Europe builds, the infrastructure it protects, and the societies that hold it together are being rebuilt with AI right now. Europe holds around 5% of the world's AI compute and moves slower than its competitors. It bets that the way it builds, with trust, fairness and collaboration designed in from the start, is not a cost but the only way to build what lasts.
Is that bet Europe's superpower, or its bottleneck? The summit runs on the three doctrines competing to answer that. We do not pick a winner. The tension is the programme.
01 Accelerate
The sovereignty and capability case. Build the stack or stay exposed.
02 Simplify
The single-market and scale case. Cut the friction, let solutions scale.
03 Protect
The fairness and trust case. Make trust in Europe's edge.
PROGRAM
Arrival & Welcome Coffee
14:00
Welcome & Opening
Welcome by Startup Guide | Casa do Impacto | ACT
14:30
Opening Debate
The Human Advantage: Superpower or Bottleneck? Accelerate, Simplify and Protect, live and in tension.
Keynote
Building the Critical Systems for a Resilient Europe
Fireside Chat
From Debate to Practice:
What Accelerate, Simplify and Protect Mean for Founders
Pitch Competition & Breakout Sessions
Critical Systems: 10 early-stage startups pitch solutions that future-proof the systems Europe runs on.
Hosted by Impact Shakers and LSE Generate
BR1 · Accelerate Track
With S9+ Coalition
BR2 · Simplify track
With ACT
16:00
Closing Keynotes
Educating for What AI Can't Replace — Why inclusive AI, one that expands who gets to build and benefit, may decide whether AI strengthens society or deepens its divides.
With LSE Generate
17:45
Fireside Chat
Building the Human Edge
How can we rethink creativity, education and entrepreneurship in the AI era to strengthen our societies?
With LSE Generate | Startup Guide
Panel
Can Europe Be Both Ethical and Competitive in Building the Systems It Depends On?
Pitch Competition Winner & Closing Remarks
Community Drinks & Celebration
Community gathering with music, drinks and snacks.
19:00
SPEAKERS
LJ is the Head and Co-founder LSE Generate, managing the entrepreneurship centre in London and its international chapters across the globe. Prior to joining LSE, LJ founded and led a careers and recruitment consultancy focused on climate and sustainability sectors, and earlier in her career worked in television and media. Her work focuses particularly on social innovation, healthy ageing, and mission-driven entrepreneurship, with a strong interest in how innovation ecosystems can contribute to more inclusive and sustainable futures. In 2026, she was awarded an MBE for services to social innovation and education.
Mike Sax is the Founder of Wellbeyond. Mike is also founder and chairman of the Association for Competitive Technology (ACT), a non-profit organization that helps policy makers understand the impact of proposed legislation on small business innovators.
Nuno Comando is the Director of Casa do Impacto. Fusing his experience and diverse background in marketing and communications, digital, management and entrepreneurship with his unwavering commitment to positive social change, he has contributed to Casa do Impacto's mission and has been involved with SCML's Hub since its early days. Casa do Impacto is the most significant impact entrepreneurship Hub in Portugal. Since its opening in 2018, this 'Casa' has put Portugal on the map of the impact ecosystem, gathering the resources and network to grow an impact venture/organization. Recognized by the Financial Times as one of Europe's Leading Hubs for Startups, Casa do Impacto is where stakeholders converge to change the business paradigm. The hub's unwavering focus on creating an exciting pipeline of solutions aligned with the 17 SDGs through acceleration, investment, and incubation programs ensures its mission aligns with the global sustainability agenda.
Torsten leads policy and strategy at Danske Iværksættere, working to strengthen the framework conditions for entrepreneurs and scaleups in Denmark and across Europe. He brings a rare blend of experience spanning regulatory affairs, public affairs, and international business, having previously headed government affairs at British American Tobacco and worked in political campaigning. He holds an MSc in Political Science from the University of Copenhagen. At Danske Iværksættere, Torsten focuses on building the dialogue between policymakers and the startup ecosystem, ensuring entrepreneurs have a clear and credible voice in shaping the regulatory landscape that affects their growth.
More speakers soon
Pitch Competition

Calling all early-stage founders across Europe and the UK building the systems we cannot afford to lose.
10 startups. 5-minute pitch.
Live at the Summit in front of founders, investors and policymakers.
Applications open until October 9, 2026
HOSTs
Startup Guide is a leading publisher of guidebooks and digital content for over 60 international startup ecosystems. Startup Guide mission is to leverage experience and diverse networks to connect local solutions with global challenges, driving impactful innovation on an international scale.

The App Association is a global trade association for small and medium-sized technology companies. Our members are entrepreneurs, innovators, and independent developers within the global app ecosystem that engage with verticals across every industry.
location

Casa do Impacto is a Hub powered by Santa Casa da Misericórdia de Lisboa where all the major social and innovation players/initiatives in Portugal are gathered at a restored convent in Lisbon City Center. Combining experienced startups and projects with early-stage entrepreneurs, an incubation space, acceleration programs, events and a philanthropic fund for early-stage social and impact startups.

